Added: Teagan Holman - Date: 14.02.2022 20:35 - Views: 30291 - Clicks: 3276
I am a medical microbiologist who has worked for many years in the area of infections of medical devices. My laboratory focuses on development of novel antimicrobials that have applications as antibiotics and disinfectants. We also develop new antimicrobial coatings that can be used for a variety of purposes, including coating of medical devices to reduce associated infections.
We have taken several of these through to pre-clinical testing, and antimicrobial contact lenses through to Phase III clinical trials. Within the area of contact lens research, we focus on understanding the aetiology of adverse events and comfort during contact lens wear.
Our research includes adhesion and biofilm formation of ocular pathogenic microbes most notably Pseudomonas aeruginosa and Staphylococcus aureus. This research involves the study of microbial pathogenesis, and mammalian tissue responses to microbes and biomaterials. We have established several animal and cell-based models for studying contact lens adverse events and biomaterial infections. Our research has also encompassed proteomic and lipidomic studies of the tear film and its interaction with contact lenses.
We have applied new techniques that allow the quantification individual proteins and lipids that orb onto contact lenses, or are biomarkers for changes to the ocular surface. This allows researchers, for the first time, to be able to assess the contribution of particular proteins or lipids to the production of adverse responses during lens wear. We have also investigated the use of tears as the source of biomarkers for diabetes, breast and prostate cancer. These research studies have led to the publication of 15 patents and over peer reviewed papers.
We work closely with industry to provide potential new products, testing facilities, clinical trials and laboratory and clinical training. Breadcrumb Home. Mark Willcox. Professor and Director of Research. Book Chapters. View publication. Aristoteli L; Willcox M,'Adhesion of Pseudomonas aeruginosa to a high molecular weight glycoprotein species in human tears', in Ioseliani OR ed.
Conference Papers. Mohammad Y; Dutta D; Willcox M,'Depolarizing effect of cationic antimicrobial peptides melimine and mel-4 on bacterial cell membranes', in Depolarizing effect of cationic antimicrobial peptides melimine and mel-4 on bacterial cell membranesAustralian Society of Microbiology, Hobart, Austalia, presented at Australian Society of Microbiology, Hobart, Austalia, 02 July - 05 July Willcox M; Dutta D,'Improving the safety of the melimine-coated antimicrobial contact lenses.
Dutta D; Willcox M,'Improving the safety of the melimine-coated antimicrobial contact lenses. Dutta D; Kumar N; willcox M,'Characterisation and activity of surface attached antimicrobial peptides', in Characterisation and activity of surface attached antimicrobial peptidesInternational symposium of surface and interface of biomaterials, annual conference of the Australian society for biomaterials and tissue engineering, Sydney, presented at International symposium of surface and interface of biomaterials, annual conference of the Australian society for biomaterials and tissue engineering, Sydney, 07 April - 10 April Dutta D; Ozkan ; Willcox, 'Performance of antimicrobial contact lenses in one day human clinical study.
Dutta D; Ozkan J; Willcox M,'Biocompatibility and retention of activity of melamine antimicrobial contact lenses in a human clinical trial', in Biocompatibility and retention of activity of melamine antimicrobial contact lenses in a human clinical trialAssociation for Research in Vision and Ophthalmology, Orlando, USA, presented at Association for Research in Vision and Ophthalmology, Orlando, USA, 04 May - 08 May Ozkan J; Willcox M,'The effect of lens modulus on post-insertion comfort with silicone hydrogel lenses.
Ozkan J; Mandathara P; Krishna P; Holden B; Willcox M,'Effect of daily saline instillation and daily lens replacement during continuous wear as a means of reducing contact lens related ocular adverse events. Ozkan J; Zhu H; Willcox M,'Efficacy and clinical performance of selenium antibacterial silicone hydrogel contact lenses', in Efficacy and clinical performance of selenium antibacterial silicone hydrogel contact lensesAssociation for Research in Ophthalmology and Vision, presented at Association for Research in Ophthalmology and Vision, 28 April - 30 April Ozkan J; Zhu H; Willcox M,'Short-term overnight study with selenium antibacterial silicone hydrogel contact lenses.
Willcox MD,'Effect of contact lenses on the ocular surface and the tear film. Xue ML; Thakur A; Willcox MD,'Neutralization of macrophage inflammatory protein inhibits expression of vascular endothelial growth factor and corneal neovascularization following P aeruginosa infection in mice', in Gillies M ed. S - S, presented at 3rd international conference on the Lacrimal Gland, tear film and dry eye syndromes, Maui, Hawaii, 15 November - 18 November S85 - S85, presented at 3rd international conference on the Lacrimal Gland, tear film and dry eye syndromes, Maui, Hawaii, 15 November - 18 November S74 - S74, presented at 3rd international conference on Local sex willcox Lacrimal Gland, tear film and dry eye syndromes, Maui, Hawaii, 15 November - 18 November Willcox MD,'What do gene knockout mice tell us about the pathogenesis of keratitis?
Conference Abstracts. Conference Posters. Masoudi S; Mitchell T; Willcox M,'In vitro lipid deposition and extraction from two silicone hydrogel contact lenses', presented at Association for Research in Vision and Ophthalmology, 01 May - 05 May Masoudi S; Zhao Z; Ariyavidana A; willcox M,'Contact lens wear-induced ocular discomfort and changes to inflammatory mediators in human tears.
Conference Presentations. Conference Proceedings Editor of. Journal articles. Echeverria C; Ozkan J; Pahlevani F; Willcox M; Sahajwalla V,'Multifunctional marine bio-additive with synergistic effect for non-toxic flame-retardancy and anti-microbial performance', Sustainable Materials and Technologiesvol. Clinical Neurophysiology 1 —S Khan M; Stapleton F; Perrywillcox MD,'Susceptibility of contact lens-related pseudomonas aeruginosa keratitis isolates to multipurpose disinfecting solutions, disinfectants, and antibiotics', Translational Vision Science and Technologyvol.
Shahzad S; Willcox M; Shahzad A,'Identification of novel in vitro antibacterial action of cloprostenol and evaluation of other non-antibiotics against multi-drug resistant A. Datta A; Willcox M; Stapleton F,'In vitro antimicrobial efficacy of silver lens cases used with a multipurpose disinfecting solution', Translational Vision Science and Technologyvol. Willcox MDP,'Is there a role for inflammation in contact lens discomfort?
Watanabe K; Zhu H; Willcox M,'Susceptibility of Stenotrophomonas maltophilia clinical isolates to antibiotics and contact lens multipurpose disinfecting solutions', Investigative Ophthalmology and Visual Sciencevol. Hui A; Willcox M; Jones L,'In vitro and in vivo evaluation of novel ciprofloxacin-releasing silicone hydrogel contact lenses', Investigative Ophthalmology and Visual Sciencevol. Ocular surface health with contact lens wear', Contact Lens and Anterior Eyevol.
Willcox MD; Konda N,'Review of inflammation and infection in contact lens wearers: risk factors and association with single nucleotide polymorphisms', Journal of Ocular Biologyvol.
Willcox MD,'Management and treatment of contact lens related Pseudomonas keratitis', Clinical Ophthalmologyvol. Willcox MD,'Review of resistance of ocular isolates of Pseudomonas aeruginosa and Staphylococci from keratitis to ciprofloxacin, gentamicin and cephalosporins', Clinical and Experimental Optometryvol.
Saville J; Zhao Z; Willcox MD; Mitchell T; Blanksby S,'Detection and quantification of tear phospholipids and cholesterol in contact lens deposits: the effect of contact lens material and lens care solution', Investigative Ophthalmology and Visual Sciencevol. Schubert TL; Hume EB; Willcox MD,'Staphylococcus aureus ocular isolates from symptomatic adverse events: antibiotic resistance and similarity of bacteria causing adverse events', Clinical and Experimental Optometryvol.
Willcox MD,'Which is more important to the initiation of contact lens related microbial keratitis, trauma to the ocular surface or bacterial pathogenic factors? Aristoteli LP; Willcox MD,'The adhesion of Pseudomonas aeruginosa to high molecular weight human tear film species corresponds to glycoproteins reactive with Sambucus nigra lectin', Experimental Eye Researchvol. Volume 25, pp. Bandara BM; Sankaridurg P; Willcox MD,'Non-steroidal anti inflammatory agents decrease bacterial colonisationof contact lenses and prevent adhesion to human corneal epithelial cells', Current Eye Researchvol.
August, pp. Zhu H; Thuruthyil SJ; Willcox MD,'Determination of quorum-sensing al molecules and virulence factors of Pseudomons aeruginosa isolates from contact lens-induced microbial Local sex willcox, Journal of Medical Microbiologyvol.
Xue ML; Thakur A; Willcox MD,'Macrophage inflammatory protein-2 and vascular endothelial growth factor regulate corneal neovascularization induced by infection with Pseudomonas aeruginosa in mice', Immunology and Cell Biologyvol. Willcox MD,'Inflammation and infection and the effects of the closed eye', Opticianpp. Thakur A; Willcox MD,'Contact lens wear alters the production and function of certain inflammatory mediators in tears', Experimental Eye Researchvol.
Aetiology and management: a review. Part 1. Factors influencing distribution of Candida species in the oral cavity', Australian Dental Journalvol. Part 3. Treatment of oral candidosis', Australian Dental Journalvol. Thakur A; Willcox MD,'Cytokines and lipid inflammatory mediator profile of human tears of contact lens associated inflammatory disease', Experimental Eye Researchvol. Part 2.
Oral diseases caused by candida species', Australian Dental Journalvol. S17 - S S33 - S S43 - S S23 - Local sex willcox S36 - S S39 - S S30 - S S27 - S Willcox MD,'Potential pathogenic properties of members of the streptococcus milleri group in relation to the production of endocarditis and abcesses', Journal of Medical Microbiologyvol. Willcox MDP; Knox KW,'A comparison of the adhesion profiles and cell surface characteristics of streptococcus mitis with those of other members of the streptococcus sanguis group', Microbial Ecology in Health and Diseasevol.
Willcox Drucker MDPDB,'Partial characterisation of the inhibotory substances produced by streptococcus oralis and related species', Microbiosvol. Area of expertise.Local sex willcox
email: [email protected] - phone:(688) 164-5552 x 7419